Summary: Chondrichthyan (cartilaginous fish) occupies a key phylogenetic position and is important for investigating evolutionary processes of vertebrates.However, limited read more whole genomes impede our in-depth knowledge of important issues such as chromosome evolution and immunity.Here, we report the chromosome-level genome of white-spotted bamboo shark.Combing it with other shark genomes, we reconstructed 16 ancestral chromosomes of bamboo shark and illustrate a dynamic chromosome rearrangement process.
We found that genes on 13 fast-evolving chromosomes can be enriched in immune-related pathways.And two chromosomes contain important genes that can be used to develop single-chain antibodies, which were shown to have high affinity to human disease markers by using enzyme-linked immunosorbent assay.We also found three bone formation-related genes were lost due to chromosome rearrangements.Our study highlights the importance of chromosome rearrangements, providing resources for understanding of ps5 price new jersey cartilaginous fish diversification and potential application of single-chain antibodies.