Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation[S]

ABCA1 plays a major role in HDL metabolism.Cholesterol secretion by ABCA1 is dependent on the presence of extracellular acceptors, such as lipid-free apolipoprotein A-I (apoA-I).However, the importance of the direct interaction between apoA-I and ABCA1 in HDL formation remains unclear.In contrast, ABCB4 mediates the secretion of phospholipids and c

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The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish

Summary: Chondrichthyan (cartilaginous fish) occupies a key phylogenetic position and is important for investigating evolutionary processes of vertebrates.However, limited read more whole genomes impede our in-depth knowledge of important issues such as chromosome evolution and immunity.Here, we report the chromosome-level genome of white-spotted b

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